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KMID : 0369819960260020125
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Jorunal of Korean Pharmaceutical Sciences
1996 Volume.26 No. 2 p.125 ~ p.135
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Preparation and Drug Release Profiles of Solid Lipid Nanoparticles (SLN)
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유혜종/Yoo HJ
김길수/Kim KS
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Abstract
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Solid lipid nanoparticles(SLN) are particulate systems for parenteral drug administration and suitable for controlled release. SLN were prepared by homogenization process. Dispersion at increased temperature (molten lipid) was performed to yield SLN loaded with lipophilic drugs. Tetracaine base, lidocaine base, prednisolone, methyltestosterone and ethinylestradiol were used as model drugs to access the loading capacity and to study the release behavior. To investigate production parameters(lipids, surfactant concentration, homogenizing rpm) in the formation of SLN, particle size was performed by laser diffraction analysis. The mean particle size of SLN with stearic acid or trilaurin was below 1 micron. By decreasing the particle size and increasing the surfactant concentration, the release rate was increased especially in the case of highly lipophilic drug loaded SLN. Methyltestosterone or ethinylestradiol loaded SLN showed a distinctly prolonged release over a few days.
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KEYWORD
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Solid lipid nanoparticles(SLN), Particulate systems, Lipophilic drugs, Particle size, Prolonged release
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